Thrombocytes and its Structures

Thrombocytes, commonly known as blood platelets are an important part of the blood. Their quantity is quite essential to maintain in blood. The Thrombocyte are also known as platelets, they need to be maintained in the blood with a certain quantity failing which the mammals can face the various health disorders. The Thrombocytes main purpose is the Hemostasis, as they are used to stop bleeding and at the site causing the interrupted endothelium. There are three stages of the Hemostasis, and we have discussed them below:

  • Adhesion: In the first step the platelets gets attached outside surface of the uninterrupted endothelium.
  • Activation: They start changing their shapes, turns on the receptors and start secreting the chemical messengers.
  • Aggregation: The platelets start connecting to each other through receptor bridges.

It clearly displays how the platelets function in stopping the bleeding so that blood should not freely flow from the body if any injury happens. The Thrombocyte have a structure too, which is comprised of different membranes.

Let’s talk about the structure of Thrombocyte:

Their structure is comprised of four different zones, we will study them from the peripheral to the innermost:

  • Peripheral Zone: The outer part of the zone is made up of glycoprotein for the adhesion of platelets, their aggregation and activation too. For e.g. GPIIb/IIIa, GPVI etc.
  • Sol-gel Zone: The second outermost layer is said to be rich in microfilaments and microtubules, and they help in maintaining the discoid shape of platelets in the blood.
  • Organelle Zone: The third most peripheral zone of the is rich in alpha granules, protein granules and also contains clotting mediators like factor VIII, factor V, fibrinogen, platelet derived growth factors, chemotactic agents and fibronectin. Dense bodies or delta granules also contain Serotonin, Calcium and ADP, which are considered as platelet activating mediators.
  • Membranous Zone: The Membranous zone is the innermost zone, which contains various other membranes derived from megakaryocytic smooth endoplasmic reticulum and is said to be organized into a deep tense kind of tubular system. This tubular system is also used in the synthesis of thromboxane A2 and also connects to the various surface platelet membranes to aid the release of thromboxane A2.

These layers of the platelets are differentiated from each other and also helps in the smooth function of the platelets. They should not be present in the blood in excessive nor in below average numbers. The Thrombocyte concentration is measured by hemocytometer through manual methods or they can also be measured by placing blood in automated platelets analyzer which is known as electrical impedance.

The platelets routine check-up is very important, as you should always know that they should be present in your blood in sufficient amount. The Thrombocyte are an important part of the blood, and they are quite small in size and that is why are present in small fractions, otherwise their quantity is much more than if compared to white blood cells. So, do not underestimate their presence so check them and maintain their quantity and visit the nearby doctor if you are feeling that they are not working efficiently.

 

Image courtesy of [Toeytoey] at FreeDigitalPhotos.net



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